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The Progress Report Progress never stops. Stay informed with the latest news on breast cancer research, treatment, and prevention.


Tumor Biology x

Dr. Matthew Ellis in his lab at Baylor College of Medicine.

Proteogenomics allows for simultaneous, multi “-omic” analyses of DNA, RNA (genomics), and proteins (proteomics) in a tissue sample. The information from this set of analyses can identify why a tumor is resistant to treatment and open possibilities for other effective therapies going forward.

A tumor is not made up of just cancer cells. Within a tumor there is an entire ecosystem of both cancer and non-cancer cells interacting with each other. This is known as the tumor microenvironment.

A BCRF investigator since 1998, Dr. Michael Wigler along with BCRF colleague, Dr. James Hicks pioneered single cell analysis, the process of isolating single tumor cells to study the underlying tumor biology.

Research has fueled advances in early detection, prevention and treatments that have had significant impact on breast cancer outcomes. Many women are living longer after diagnosis—there are nearly 3 million breast cancer survivors in the U.S. today.

BCRF sat down with Dr. Titia de Lange to discuss her current work and interest in breast cancer research. Read on to learn more.


Q: How did you become interested in breast cancer research?

BCRF sat down with Dr. H. Shelton Earp to discuss his current work and interest in breast cancer research. Read on to learn more.


Q: Tell us a little about yourself and how you became interested in breast cancer research.