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BCRF Investigator Since

2017

Donor Recognition

The Wythes Family Foundation Award

Area(s) of Focus

Daniele Gilkes, PhD

Assistant Professor of Oncology
Assistant Professor Chemical and Molecular Engineering
Johns Hopkins University School of Medicine
Baltimore, Maryland
Jayne Koskinas Ted Giovanis Foundation for Health and Policy Partnership

Current Research

  • Seeking to understand the timing and requirements for metastasis.

  • Using both mathematics and cancer biology to chart the process of metasasis.

  • These innovate cross-disciplinary studies will accelerate our understanding of metastasis and guide new therapy development to prevent metastasis in breast cancer survivors.

Hypoxia, or low amounts of oxygen, is a feature of most breast tumors and is associated with breast cancer metastasis and poor outcomes. 

In this project co-funded by BCRF and Jayne Koskinas Ted Giovanis Foundation for Health and Policy, Dr. Gilkes’s tumor biology expertise and Dr. Macklin’s computational expertise combine to gain novel insights in tumor growth and metastasis.

Drs. Gilkes and Macklin will use a signal to detect low oxygen levels to label and track cancer cells during tumor progression. They will then use mathematical modeling approaches to combine experimental time course data analyzed with digital pathology of primary and metastatic sites to understand the timing and prerequisites for metastasis.

Bio

Daniele Gilkes earned her MS in engineering from the University of Florida and her PhD in cancer biology from the University of South Florida. She is currently an assistant professor in the departments of Oncology as well as Chemical and Molecular Engineering at the Johns Hopkins University School of Medicine. Her research goal is to develop a breast cancer research program which utilizes new technologies that can rapidly advance our understanding of how the microenvironment, in particular hypoxia and hypoxia-induced genetic changes, promote breast cancer metastasis. The overall objective is to identify therapeutic strategies that focus on metastasis treatment and prevention strategies for breast cancer patients.

Co-Investigators