Department of Public Health Sciences
The University of Chicago
Seeking to understand the disparity in breast cancer incidence and outcomes in women from different ethnic backgrounds.
Ongoing studies are focused on determining the genetic factors that contribute to aggressive breast cancers in diverse groups of women.
This work will provide new insights into the disparate incidence of triple negative breast cancer in African American women and inform population-specific screening and preventive strategies.
Triple negative breast cancer (TNBC) remains a huge clinical challenge and disproportionately affects young women and women of African ancestry. Advances in our understanding of the human genome (the genes in our DNA) have allowed development of new ways to treat TNBC by targeting pathways that are dysregulated in the tumor.
We now know that non-genetic factors act in concert with lifestyle and other risk factors to cause aggressive breast cancer. The work of Drs. Huo and Olopade is focused on identifying patterns in the DNA of women from different ethnic backgrounds that may help to explain genetic differences in breast cancer incidence and outcomes.
Using tumors from indigenous Africans, African Americans, and White Americans, the team identified a gene called GATA3 that is mutated in breast cancer in proportion to African ancestry. The biological processes that cause the mutation vary across ethnic backgrounds.
This year, they will examine how the mutations in genes such as GATA3 contribute to aggressive behavior of breast cancer and how epigenetic modifications of DNA (chemical modifications to DNA that affect expression of genes) contribute to the process.
Their ultimate goal is to use this knowledge to develop effective diagnostic tools for personalized risk prediction and novel therapies for personalized cancer medicine in diverse populations of women.
Dezheng Huo is Associate Professor of Epidemiology in Department of Public Health Sciences with joint appointment in Department of Medicine at the University of Chicago. Dr. Huo's research spans across several areas of breast cancer research, including: 1) the genetic and environmental factors underlying the etiology of breast cancer, particular in women of African ancestry; 2) epigenetics, non-coding RNAs, and the prognosis of breast cancer; 3) treatment utilization and health disparity in breast cancer patients. Using genome-wide association study and whole genome sequencing approach, Dr. Huo has been investigating the genetic factors for breast cancer in women of African ancestry. Collaborating with researchers in a consortium, he seeks to develop a genetic risk prediction model to predict breast cancer risk for African Americans. He also completed a pilot study identifying microRNAs in circulation that can predict breast cancer recurrence. Dr. Huo conducted systemic investigations of the utilization of hormonal therapy, radiotherapy, and surgery in breast cancer patients, as well as outcome disparity due to nonadherence to guidelines. He is exploring the influence of lifestyle factors and comorbidity on survival outcomes in breast cancer survivors using a perspective cohort study of multiple ethnicities.