Dana-Farber Cancer Institute Boston, Massachusetts
Associate Director, Susan F. Smith Center for Women’s Cancers
Improving treatments for people with hormone receptor-positive, HER2-negative metastatic breast cancer.
Recent results from the Phase 3 TROPiCS-02 clinical trial showed that the antibody-drug conjugate sacituzumab govitecan (Trodelvy®) was more effective than chemotherapy for patients with hormone receptor (HR)-positive, HER2-negative breast cancer that has developed resistance to endocrine therapy. Sacituzumab govitecan damages the DNA within cancer cells, drawing immune cells into the tumor. Studies suggest that pairing sacituzumab govitecan with the immunotherapy pembrolizumab may have even greater anti-tumor immune activity. Dr. Tolaney is testing this combination therapy in patients with HR-positive, HER2-negative metastatic breast cancer.
Dr. Tolaney is conducting a clinical trial in which patients with HR-positive, HER2-negative metastatic breast cancer that has progressed on other treatments receive either sacituzumab govitecan alone or sacituzumab govitecan and pembrolizumab. In addition to measuring the effectiveness of the combination on tumor response, the team will collect tumor samples to investigate how cancer develops resistance, how the treatment alters gene expression within the tumor, and the role of different types of immune cells on treatment outcomes.
Sara Tolaney, MD, MPH is the Chief of the Division of Breast Oncology at Dana-Farber Cancer Institute and internationally recognized for her research and education leadership in breast cancer. She also serves as Associate Director of the Susan F. Smith Center for Women’s Cancers and is a Senior Physician at Dana-Farber Cancer Institute and Associate Professor of Medicine at Harvard Medical School. Dr. Tolaney received her undergraduate degree from Princeton University and her medical degree from UC San Francisco. She subsequently completed her residency in internal medicine at Johns Hopkins University, and fellowships in hematology and medical oncology at Dana-Farber Cancer Institute. She obtained her master’s degree in public health from Harvard School of Public Health.
Her research focuses on the development of novel therapies in the treatment of breast cancer and developing more effective and less toxic treatment approaches. Her work has demonstrated that a relatively low-risk regimen is beneficial in women with early-stage node-negative HER2-positive cancers, and this works has been incorporated into national and international guidelines. She has developed several follow-up studies looking at novel approaches to early stage HER2-positive disease and has also played a significant role in development of CDK4/6 inhibitors, antibody-drug conjugates, and immunotherapy in breast cancer. She currently chairs several registration studies in these areas and also leads many investigator-initiated trials. She is the author of over 150 peer-reviewed publications with manuscripts included in many prestigious journals such as the New England Journal, Lancet Oncology, Journal of Clinical Oncology, and JAMA Oncology.
2024
The Boston Hot Pink Luncheon Award in Honor of Amanda and Ben Heller
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