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HER2-ultralow breast cancer

By Elizabeth Sile | May 13, 2025

Another emerging HER2 status, HER2-ultralow breast cancer contains even fewer HER2 proteins than HER2-low and HER2-positive breast cancers. Currently, HER2-ultralow breast cancers have an immunohistochemistry (IHC) test score of 0 with HER2-positive staining in up to 10 percent of tumor cells. This status only has implications for patients with metastatic breast cancer and is not part of a routine pathology report.

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