Tyrosine kinase inhibitor (TKI)

Tyrosine kinases are enzymes that are key to cell functioning. An increase in their amount or activity can encourage cancer’s development. Tyrosine kinase inhibitors are drugs that block these actions. Tyrosine kinase inhibitors are used to treat HER2-positive breast cancers and include: lapatinib (Tykerb®), neratinib (Nerlynx®), and tucatinib (Tukysa®). They are all administered orally.