Professor of Physics and Astronomy
University of California
Irvine, California EIF/Stand Up To Cancer
Studies are aimed at improving the effectiveness of immunotherapy by studying the tumor ecosystem.
A Stand Up 2 Cancer Convergence team applies a multi-disciplinary approach to tumor biology.
This collaborative research will lead to novel treatment approaches that modify the tumor environment to improve anti-tumor immunity and response to immunotherapy drugs.
Tumors consist not only of cancer cells, but also stromal and immune cells that constitute the tumor microenvironment (TME). The TME is an ecosystem of multiple cell populations, and the extracellular matrix (ECM) that they produce, that interact in a complex fashion to yield tissue form and function.
Cancer cells can take on dramatically different properties based on influences from the microenvironment. In many different cancer types, including breast cancer (BC), tumors with more stromal cells typically have worse clinical outcomes. In contrast, tumors infiltrated by a type of immune cell called CD8 T cells have better clinical outcomes. Hence, tumors behave differently based on the collective behavior of the microenvironment.
The objective of the Stand Up 2 Cancer (SU2C) Convergence team consisting of Drs. Atwal, Irvine, Lee, Levine and Yu is to apply systems and ecological approaches to study the TME and determine whether it is an important determinant for the efficacy of cancer immunotherapy.
The SU2C team brings together expertise in high dimensional histology, image analysis, culturing cells from primary human breast tumors, 3D spheroids, bioinformatics, ecology modeling, and nanotechnology to study the ecology of the TME in BC, and develop therapeutic and imaging applications.
In the first year of their award, the SU2C team showed that cancer-associated fibroblasts and other immune-derived cells interact with cancer cells to promote tumor progression and metastasis. They also found the addition of a commonly used drug to treat parasitic infection improved reponse to anti PD-1/PD-L1 immunotherapy.
They are continuing these investigations to understand the relationship between the stromal cells and cancer cells and develop targeted approaches to improve response to treatments.
Dr. Yu trained as a condensed matter theoretical physicist and has extensive experience in modeling of complex systems using techniques from statistical physics, Monte Carlo simulations, and molecular dynamics simulations. Dr. Yu uses modeling to explain and predict experimental data and observations. More recently, she has been involved in using computer simulations to model intracellular transport and growth control via the Fat signaling pathway in Drosophila embryos. Her current focus is cancer, especially tumorigenesis.