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Graham A. Colditz, DrPH, MD, MPH
Niess-Gain Professor of Surgery and Professor of Medicine
Chief, Division of Public Health Sciences, Department of Surgery
Associate Director Prevention and Control
Alvin J. Siteman Cancer Center
Deputy Director, Institute for Public Health
Washington University School of Medicine
St. Louis, Missouri
Seeking to understand how early life behaviors influence future breast cancer risk.
Studies are ongoing to analyze components of diet including fruit and vegetable intake in relation to risk of benign breast lesions and other markers of breast cancer risk.
These studies may lead to targeted interventions and health promotion in young adults to reduce the risk of breast cancer.
Dr. Colditz specializes in studies on childhood and adolescent lifestyle and growth, combining these with insights on breast development to identify potential prevention strategies to reduce breast cancer risk starting early in life.
This year, the group will focus on the importance of a healthy diet, as measured by fruit and vegetable intake, in relation to risk of benign breast lesions and other markers of breast cancer risk. Findings from this work could provide new evidence of the importance of the adolescent and early adult diet to reduce breast cancer risk.
Dr. Colditz is also examining data from women enrolled in the Nurses Health Study II to assess childhood and adolescent growth and lifestyle factors including obesity, peak height growth velocity, adolescent alcohol intake, and physical activity, in relation to markers of cell growth in normal breast tissue. Results may indicate the importance of these body measurements and lifestyle choices on breast cancer risk.
Dr. Colditz is an epidemiologist and public health expert with a longstanding interest in the causes and prevention of chronic disease, particularly among women. With a commitment to identifying strategies for prevention of breast cancer, Dr. Colditz studies benign breast disease and other markers for risk of breast cancer. Dr. Colditz described the increase in risk of breast cancer with use of combined estrogen plus progestin therapy and a significant increase in risk with increasing duration of use. Mortality from breast cancer was also elevated among current users (NEJM 1995). These data were confirmed by the WHI. He documented in prospective data the importance of proliferative benign lesions and risk of subsequent breast cancer (JAMA 1992; NEJM 1999) and the potential for childhood and adolescent diet, alcohol, and adiposity to modify risk of premalignant and invasive breast cancers. His research continues to focus on this time period in women’s lives and prevention of breast cancer. He is among the most highly cited medical researchers in the world.
Dr. Colditz developed the award-winning Your Disease Risk website (www.yourdiseaserisk.wustl.edu) which communicates tailored prevention messages to the public. He has published over 900 peer-reviewed publications, six books and contributed to reports for the Institute of Medicine, National Academies of Science.
Dr. Colditz has served in numerous leadership roles. He was the editor-in-chief of the journal Cancer Causes and Control and has contributed to reports of the Surgeon General on Tobacco and Health. In October 2006, on the basis of professional achievement and commitment to public health, Dr. Colditz was elected to membership of the Institute of Medicine, an independent body that advises the U.S. government on issues affecting public health. He received the ACS Medal of Honor in 2011, the AACR-AACS award in 2012, and the ACSO-ACS award in 2014, all recognizing his research in cancer prevention and control.
BCRF Investigator Since
The ANN INC. Award
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