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Jeffrey N. Weitzel, MD

Director, Clinical Cancer Genetics Program
Professor of Oncology and Population Sciences
Beckman Research Institute, City of Hope
Duarte, California

Current Research

Goal: To improve access to genetic screening and breast cancer prevention in Latin America and Mexico.

Impact: Dr. Weitzel’s work is focused on identifying barriers that prevent Latin American people from undergoing breast cancer risk assessment and counseling. His efforts, which include training clinicians to conduct genetic screening in underserved areas, could potentially save the lives of many women at risk of breast cancer in South America and Mexico.

What’s next: He and his colleagues will continue to expand access to genetic testing and risk-reduction surgery for Latin American women.

While genetic testing and counseling for breast cancer has been available in the US for many years, accessing these services in Mexico and Latin America is more challenging due to limited resources. This disparity is particularly concerning because hereditary breast cancer has been found to be a serious problem in these groups of women. Dr. Weitzel is addressing this issue by implementing genetic cancer risk assessment and training clinicians in the region so that women at the highest risk of breast cancer can be identified and receive the preventive care they need.

Full Research Summary

Research area:  Expanding access to genetic screening and breast cancer prevention in Latin America.

Impact: Breast cancer risk reduction includes genetic cancer risk assessment. However, accessing genetic counseling, detecting high-risk individuals and offering treatment requires an infrastructure that support public access to both genetic testing and prophylactic surgery. Access to these services is limited in Latin America. Dr. Weitzel and his colleagues are addressing this need by providing necessary infrastructure for genetic counseling in Latin America. Their aim to show that cancer care can reach beyond limited resources, and that low- and middle-income countries can benefit from genetic screening and lifesaving interventions in high-risk individuals.  

Current research: Dr. Weitzel and his international colleagues are addressing breast cancer treatment and prevention disparities across the age spectrum, and across the Americas, by increasing implementation of genetic risk assessment  and preventive services.

What he’s learned so far: Dr. Weitzel’s studies have benefited more than 1500 women, and through genetic cancer risk assessment they have detected over 150 new high-risk families, including BRCA mutation carriers. In Latin American countries, where they have implemented genetic screening services, they noted an increase in risk reducing surgery.

What’s next: He and his colleagues will continue their efforts to enhance the capacity of genetic cancer risk assessment, monitor follow-up care, and expand the spectrum of breast cancer genes being studied.


Jeffrey N. Weitzel, MD is Chief of the Division of Clinical Cancer Genetics and the Cancer Screening & Prevention Program at the City of Hope Comprehensive Cancer Center in Duarte, California. Dr. Weitzel is Board Certified in clinical genetics and medical oncology, and he is a Professor of Oncology and Population Sciences at the City of Hope. At the vanguard of personalized medicine, Dr. Weitzel’s multidisciplinary clinical, research, and training programs emphasize translational research in genomic cancer risk assessment, chemoprevention, targeted therapy, clinical and psychosocial outcomes, genetic epidemiology and health services research in underserved minorities, and hereditary cancer in Latin America. He is a member of the American Society of Clinical Oncology and the NCCN Genetics/Familial Risk Assessment practice guidelines committee. Dr. Weitzel is the principal investigator for the City of Hope Cancer Genetics Education Program and for the Clinical Cancer Genetics Community Research Network, which are funded by the National Cancer Institute.

Large Researcher Headshot - Weitzel Jeffrey

BCRF Investigator Since


Donor Recognition

The Gray Foundation and BCRF Collaborative Award