Kathleen & Stanley Glaser Professor of Medicine
Deputy Director, Sylvester Comprehensive Cancer Center
University of Miami
Seeking to understand how communication between breast cancer cells and non-cancer cells contributes to tumor progression and metastasis.
Laboratory studies are ongoing to characterize the function of a protein called RAGE and identify other factors that may contribute to its activity in promoting metastasis.
This work may lead to the development of novel weapons to add to the arsenal against metastatic breast cancer to extend the lives of patients.
Despite great strides in treatment for localized breast cancer, metastatic breast cancer remains an overwhelmingly lethal disease. Most breast cancer research has focused on breast cancer cells themselves to identify mechanisms of disease progression.
Dr. Lippman's research efforts this year will focus on how communication between breast cancer cells and non-cancer cells of the breast tumor microenvironment contributes to tumor progression and metastasis.
They have shown that targeting a specific protein, called RAGE, can prevent breast cancer metastasis in laboratory models. Using sophisticated pharmacological and genetic methods to manipulate RAGE signaling in breast cancer cells and non-cancer cells in the tumor microenvironment, they will evaluate the role that RAGE has in establishing a pro-tumor and metastasis-promoting microenvironment.
They will identify additional factors that are responsible for recruiting and activating cells that impair immune function, and will determine if drugging these factors can prevent breast cancer metastasis.
Finally, they will determine if RAGE is a critical factor that enables cancer associated fibroblasts (CAFs) to drive metastasis of breast cancer cells. These research efforts may yield actionable biomarkers and will lead to the development of novel weapons to add to the arsenal against breast cancer.
Marc E. Lippman, MD, MACP FRCP is the Kathleen and Stanley Glaser Professor of Medicine at the University of Miami Leonard School of Medicine, and was Chairman of the Department of Medicine from May 2007 to May 2012. He is currently Deputy Director of the Sylvester Comprehensive Cancer Center. Previously Dr. Lippman was the John G. Searle Professor and Chair of Internal Medicine at the University of Michigan. From 1988 through 1999 he was Professor of Medicine and Pharmacology and Chair, Department of Oncology, at Georgetown University in Washington, DC, and served as Director of the Lombardi Cancer Center. Dr. Lippman served as Head of the Medical Breast Cancer Section, Medicine Branch, at the NIH. He completed a Fellowship in Endocrinology at Yale Medical School from 1973-1974. He was Clinical Associate at the NCI from 1970-1971 and Clinical Associate at the Laboratory of Biochemistry of the NCI. From 1970-1988 he served as an Officer and Medical Director of the United States Public Health Service. Dr. Lippman completed his residency on the Osler Medical Service, John Hopkins University Hospital from 1968-1970. He has received numerous awards including Clinical Investigator Award, American Federation for Clinical Research in 1985; Transatlantic Medal and Lecture, British Endocrine Societies, 1989; the Astwood Award, Endocrine Society, 1991; the Bernard Fisher Award, University of Pittsburgh in 1991; the AACR Rosenthal Award in April 1994, and the Brinker Award for Basic Science of the Komen Foundation in 1994.