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Stanislav Emelianov, PhD
Joseph M. Pettit Endowed Chair
Georgia Research Alliance Eminent Scholar
Professor of Electrical & Computer Engineering and Biomedical Engineering
Georgia Institute of Technology and Emory School of Medicine
Goal: To develop novel strategies for breast cancer imaging and image-guided therapy.
Impact: Dr. Emelianov and his team have created new medical imaging devices and agents to detect, differentiate, treat, and monitor breast cancer and lymph node metastases. Such technology will help provide a comprehensive approach to the clinical management of breast cancer.
What’s next: The team will continue to focus on the development and clinical translation of an advanced imaging technology that combines complementary imaging techniques to visualize regional lymph nodes of breast cancer patients. Dr. Emelianov is also developing nanoparticles to aid in imaging and therapeutic delivery.
When patients undergo breast cancer therapy, imaging is used to determine whether the cancer has spread to other tissues so that treatment plans can be adjusted to prevent metastasis. Dr. Emelianov is studying advanced imaging methods that provide highly detailed information about cancer cells, which will help him develop an imaging platform capable of non-invasive and safe diagnostic imaging and image-guided therapy of breast cancer, a technology called theranostics.
Full Research Summary
Research area: To augment emerging imaging technologies with molecularly targeted nano-sized agents to aid in breast cancer diagnostic imaging and image-guided therapy.
Impact: Dr. Emelianov’s imaging technology will provide patient-specific information and, therefore, play a critical role in more accurate detection and characterization of breast cancer and lymph node micrometastases. Other benefits include superior targeting and guidance of tissue biopsy, image-guided interventions and non-invasive therapy, and longitudinal monitoring of breast cancer treatment outcome.
Current investigation: The team is focused on advancing clinical evaluation of the presence of regional lymph node metastases in breast cancer through emerging ultrasound imaging technologies. Determination of whether a malignancy has spread through regional lymph nodes in patients is an important factor used to develop a therapeutic plan and to predict prognosis.
What he’s accomplished so far: With BCRF support, Dr. Emelianov’s team has created a new medical imaging and theranostic platform to detect, differentiate, treat, and monitor breast cancer and lymph node metastases and have demonstrated the utility of their system in image-guided treatment of lymph node metastases in breast cancer patients.
What’s next: Dr. Emelianov will explore the clinical utility of non-invasive, label-free imaging of regional lymph nodes of breast cancer patients. He and his team are developing and testing theranostic nanodroplets that aid in imaging and deliver a therapeutic agent. Dr. Emelianov is also developing new technologies that will enable imaging of the continuously changing tumor microenvironment that surrounds and interacts with tumor cells.
Dr. Stanislav Emelianov is a Joseph M. Pettit Endowed Chair, Georgia Research Alliance Eminent Scholar, and Professor of Biomedical Engineering and Electrical & Computer Engineering at the Georgia Institute of Technology. He is also appointed at Emory University School of Medicine where he is affiliated with Winship Cancer Institute, Department of Radiology, and other clinical units. Furthermore, Dr. Emelianov is Director of the Ultrasound Imaging and Therapeutics Research Laboratory at the Georgia Institute of Technology focused on the translation of diagnostic imaging & therapeutic instrumentation, and nanobiotechnology for clinical applications.
Dr. Emelianov’s career has been devoted to the development of advanced imaging methods, assisting treatment planning, and enhancing image-guided therapy and monitoring of the treatment outcome. He is specifically interested in intelligent biomedical imaging and sensing and has developed approaches for image-guided molecular therapy and therapeutic applications of ultrasound and electromagnetic energy. Dr Emelianov has pioneered several ultrasound-based imaging techniques including shear wave elasticity imaging and molecular photoacoustic imaging. Projects in Dr. Emelianov's laboratory, which focuses on cancer and other diseases, range from molecular imaging to functional imaging and tissue differentiation, from drug delivery and release to image-guided surgery and intervention.
Dr. Emelianov is a nationally recognized expert in biomedical imaging instrumentation and nanoagents for imaging and therapy. He is the author of over 500 publications including peer-reviewed research articles, invited reviews, book chapters, and conference proceedings. In recognition of his contributions to the field, Dr. Emelianov was elected to the College of Fellows of the American Institute for Medical and Biological Engineering. He is past Vice-President for Ultrasonics of the IEEE Ultrasonics, Ferroelectrics and Frequency Control Society, and senior member of several professional organizations.