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Chi-Chen Hong, PhD

Roswell Park Comprehensive Cancer Center
Buffalo, New York

Titles and Affiliations

Associate Member
Department of Cancer Prevention and Control
Roswell Park Comprehensive Cancer Center
Buffalo, New York

Research area

Understanding the molecular drivers of aggressive breast cancer in Black women and how these are different in white women.


Black women are 42 percent more likely to die of their breast cancer than white women. Those diagnosed with breast cancer are more likely to be younger than newly diagnosed white women and are two times more likely to be diagnosed with triple-negative breast cancer (TNBC), an aggressive subtype of the disease. Drs. Hong and Ambrosone are investigating several biological and lifestyle factors that may influence the incidence of TNBC in Black women. This work may provide new insights at the population level into why some women develop more aggressive breast tumors, so that personalized prevention and treatment can be designed.

Progress Thus Far

The team is studying immune cells that are in and around breast tumors, and how these types of immune cells differ between more aggressive and less aggressive tumor subtypes and between Black women and white women. They showed that some tumors appear to have a strong immune response, but the cells are actually ‘exhausted’ and dysfunctional. These findings led to a large national study to see if patients with exhausted immune cells, particularly Black women, could benefit from immunotherapy, which can re-invigorate these exhausted cells. Drs. Hong and Ambrosone also found systemic differences in immune profiles in healthy women related to a variant in the DARC gene, which evolved in African populations and stimulates a strong immune response to fight malaria infection.

What’s next

In the coming year, Drs. Hong and Ambrosone will examine whether DARC gene variants are related to breast tumor characteristics, particularly presence of immune cell types, and to survival outcomes. Understanding this may provide a piece of the puzzle as to why Black women tend to have more aggressive breast tumors.


Dr. Chi-Chen Hong is an Associate Member in the Department of Cancer Prevention and Control within the Division of Cancer Prevention and Population Sciences at Roswell Park. Dr. Hong’s research is focused on breast cancer etiology, survivorship, and prognosis. Specifically, her interests are on the influence of lifestyle, comorbidity, genetics, and immune factors. She has an ongoing prospective cohort study of early stage breast cancer patients to examine issues in breast cancer survivorship, and with colleagues at the Rutgers Cancer Institute of New Jersey and Rutgers University is principal investigator of a study examining the role of obesity and related comorbidities, including asthma and type 2 diabetes, and their management on quality-of-life and breast cancer survival outcomes among African American women, and to elucidate key pathways mediating these associations.

BCRF Investigator Since


Donor Recognition

The Play for P.I.N.K. Award


Christine B. Ambrosone, PhD

Roswell Park Comprehensive Cancer Center
Buffalo, New York