Dezheng Huo, PhD
Professor, Department of Public Health Sciences
Professor, Department of Medicine
University of Chicago Medical Center
Understanding the disparity in breast cancer incidence and outcomes in women from different ethnic backgrounds.
Dr. Huo and BCRF collaborator Dr. Funmi Olopade are part of an interdisciplinary team of scientists at the University of Chicago who are focused on expanding treatment and prevention options for women at risk for the most aggressive types of breast cancer. Their BCRF-supported research, has focused on dissecting the risk factors and genetic basis of aggressive forms of breast cancer such as estrogen receptor (ER)-negative or triple-negative breast cancer. These aggressive cancers disproportionately impact young women of African descent for reasons that are poorly understood. From mechanistic studies examining factors that contribute to the development of aggressive breast cancer in this population, they have identified mutations beyond the well-known cancer predisposition genes BRCA1 and BRCA2. Using a gene editing technology called CRISPR-Cas9, they have focused on how specific genes contribute to aggressive tumor progression.The results of their studies will help to inform the development of more personalized therapies and prevention strategies for patients affected by aggressive breast cancers.
Dr. Huo and his team have identified several pathways that are dysregulated in ER-negative breast cancer as well as several genes that contribute to the progression of aggressive tumors. Their results indicate that one of these genes may play a role in the development of malignant cancer by promoting tumor cell proliferation and resistance to cell death. They have also found that another gene, TRAIL, plays a significant role in regulating immune defense mechanisms and anti-tumor responses in ER-negative breast cancer cells—these functions affect breast cancer initiation and inflammation. In the last year, they examined how genetic variations in the TRAIL gene might contribute to aggressive types of breast cancer—analysis of these genetic variants is proceeding.
Dr. Huo and his colleagues will focus on another gene regulator of immune response and assess its role in breast cancer. The team will continue to establish laboratory models using tumor tissue from women with aggressive breast cancers. This will allow them to study the tumors and the effects of gene variants on anti-tumor immunity and immunotherapy efficacy. In addition, these models provide a novel tool for conducting initial drug testing in an environment that closely resembles the human breast environment.
Dezheng Huo is Associate Professor of Epidemiology in Department of Public Health Sciences with joint appointment in Department of Medicine at the University of Chicago. Dr. Huo's research spans across several areas of breast cancer research, including: 1) the genetic and environmental factors underlying the etiology of breast cancer, particular in women of African ancestry; 2) epigenetics, non-coding RNAs, and the prognosis of breast cancer; 3) treatment utilization and health disparity in breast cancer patients.
Using genome-wide association study and whole genome sequencing approach, Dr. Huo has been investigating the genetic factors for breast cancer in women of African ancestry. Collaborating with researchers in a consortium, he seeks to develop a genetic risk prediction model to predict breast cancer risk for African Americans. He also completed a pilot study identifying microRNAs in circulation that can predict breast cancer recurrence. Dr. Huo conducted systemic investigations of the utilization of hormonal therapy, radiotherapy, and surgery in breast cancer patients, as well as outcome disparity due to nonadherence to guidelines. He is exploring the influence of lifestyle factors and comorbidity on survival outcomes in breast cancer survivors using a perspective cohort study of multiple ethnicities.
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