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Wendie Berg, MD, PhD, FACR

University of Pittsburgh Medical Center
Pittsburgh, Pennsylvania

Titles and Affiliations

Professor of Radiology, Magee-Womens Hospital
The Dr. Bernard F. Fisher Endowed Chair in Breast Cancer Clinical Science

Research area

To improve the precision of breast cancer detection in women with a higher-than-average risk of breast cancer.

Impact

Women who have been treated for breast cancer are at increased risk for recurrence and second breast cancers. Unfortunately, current mammography is inadequate for detecting breast cancers in this population and the capacity for widespread MRI is limited and costly. Women with dense breasts also face limits in screening options since mammography can miss early lesions. Ultrasound, which is sometimes recommended for women with dense breasts, has a high rate of false positives and is also not widely available. Dr. Berg is assessing alternative methods of screening for these populations that could provide more precise results—this includes assessment of artificial intelligence to enhance ultrasound and comparing the sensitivity and specificity of 3D mammography (tomosynthesis/TO) screening alone versus 3D plus contrast-enhanced mammography (TOCEM). Since early detection of breast cancer improves outcomes and reduces the risk of recurrence or metastasis, Dr. Berg’s research will help optimize screening practices and has the potential to further reduce mortality from breast cancer.

Progress Thus Far

Dr. Berg has completed enrollment in a multi-year study (TOCEM) testing whether CEM and 3D mammography provide a feasible more effective and lower cost option of breast cancer detection than tomosynthesis alone or MRI. All patients have received their first year of screening while screening continues for cohorts of participants in their second, third and fourth years—all participants will undergo screening over four years. To date, the performance of CEM is similar to MRI, but with fewer callbacks and false positives. They have also found that patients had a better tolerance for CEM screening compared to MRI. The results of these studies will inform screening strategies by providing good estimates of cancer detection with annual CEM, interval cancer rates, and false positives. The team has initiated an added study to examine the utility of biennial screening CEM (BI-TOCEM) in women who have completed the initial three rounds of annual screening; all participants will continue to have annual 3D mammography.

What’s next

Dr. Berg and her colleagues will continue the TOCEM study with participants completing years two and three research examinations and clinical follow-up in year four. They will continue to recruit new participants to the BI-TOCEM study with a planned accrual of 1600 women. Results of these studies will help inform implementation of CEM in practice.

Biography

Wendie A. Berg, MD, PhD, FACR, is Professor of Radiology at Magee-Womens Hospital of UPMC, University of Pittsburgh School of Medicine, and is well known for her role as Study Chair and PI of ACRIN 6666, Screening Breast Ultrasound and MRI in High-Risk Women.  Dr. Berg trained at Johns Hopkins University School of Medicine where she received MD and PhD (Pharmacology) degrees in 1987 and completed residency in Diagnostic Radiology in 1992. She worked on BI-RADS Ultrasound and Mammography lexicons, has authored or coauthored over 100 peer-reviewed publications, co-writes and edits the book, Diagnostic Imaging: Breast (3 editions), has led and authored results of multicenter clinical trials evaluating breast PET, shear-wave elastography, and is currently completing a prospective multicenter study of screening ultrasound after tomosynthesis in women with dense breasts in addition to starting a prospective study of contrast-enhanced mammography vs. tomosynthesis in women with a personal history of breast cancer.

She was elected an honorary fellow of the Austrian Roentgen Society in 2012 for her contributions to the design of the Austrian Breast Cancer Screening Program. Recognizing her efforts to evaluate and implement supplemental screening methods for women with dense breasts, Dr. Berg received the 2012 Global Breast Cancer Medical Achievement Award from the Avon Breast Cancer Crusade. In 2013, she was awarded the Pathfinder lectureship of the American Society of Breast Disease, and in 2015 she received the Pink Ribbon Award from the Pennsylvania Breast Cancer Coalition. Dr. Berg is Chief Scientific Advisor to www.DenseBreast-info.org.

BCRF Investigator Since

2016

Areas of Focus

Lifestyle & Prevention